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STUDIES OF THE EFFECTIVENESS OF USING THE DRUG "LIN CHI" IN THE CLINIC OF INTERNAL DISEASES

The aim of the clinical study was to evaluate the effectiveness, safety of the drug "Lin Chi" and to study its effect on the functional state and course of the disease in persons with hepatobiliary pathology in combination therapy.

The study involved 36 patients aged 21 to 64 years who suffered from bile duct dyskinesia, chronic cholecystitis, hepatitis. The average duration of the disease was 10.2 years (1 to 13 years). In 13 of 36 patients (29%) diseases of the hepatobiliary system were detected for the first time, in the remaining 23 (71%) recurrences and complications of the underlying disease were observed. In the study group were observed: chronic hepatitis - 8 cases; chronic cholecystitis - 10 cases; chronic pancreatitis - 9 cases, chronic cholecystocholangitis - 8 cases, Gilbert's disease - 1.

The control group consisted of 22 men with hepatobiliary pathology in whom the drug "Lin Chi" was not used in addition to basic therapy.

The results showed that the use of the drug "Lin Chi" in addition to basic therapy leads to significant positive changes, both during the disease and reduces the bed-day rate in the hospital in patients with the following diagnoses: exacerbation of chronic calculous and non-calculous cholecystitis , which occurred against the background of mixed dyskinesia of the gallbladder and bile duct sphincters, as well as in persons who underwent cholecystectomy for gallstone disease and chronic hepatitis. With chronic persistent hepatitis, the bed-day decreased by 4.2 days.

One of the criteria for the effectiveness of treatment with the drug "Lin Chi" was the timing of the disappearance of clinical symptoms of the underlying disease and dyspeptic syndrome. 29 patients before treatment had weakness, irritability, 27 patients - bloating, 27 patients - belching, 25 patients - pain in the epigastrium and right hypochondrium, 23 patients had heaviness in the right hypochondrium and loss of appetite (absence), in 22 patients there were sleep disturbances, in 19 patients - constipation was observed.

In patients who, in addition to basic therapy, received drugs "Lin Chi" clinical symptoms began to disappear gradually within 3 to 7 days, only in 4% of cases there were constipation, 10% - appetite disorders, 20% and 25% - disorders sleep and irritability, but these symptoms have been observed in individuals with comorbid conditions such as neurocirculatory dystonia or hypertension.

The main criteria for the effectiveness of treatment were such general clinical symptoms as: normalization of body temperature, normalization of appetite, reduction of pain, disappearance of skin reactions (itching, rash), increased daily diuresis, normalization of blood formula (ESR, white blood cell count) and biochemical parameters.

The use of "Lin Chi" did not cause significant changes in the indicators of the general blood test, which can be considered as the absence of adverse effects of the drug and its side or toxic effects. It should be noted that when prescribing the drug "Lin Chi" there was a decrease in ESR - by 33% compared with 23% - in persons who received only basic therapy. The reduction in the number of leukocytes with the use of Lin Chi was also statistically significant. Laboratory and clinical indicators indicate the disappearance of the general inflammatory process, the phenomena of intoxication, as well as increased detoxification function of the liver and improved metabolic processes. Normalization of biochemical parameters (ALT, AST) indicates an improvement in metabolic processes in the liver at the level of hepatocytes.

The normalization of the functional state of the gallbladder and the sphincter apparatus of the biliary tract is evidenced by instrumental studies performed using ultrasound (ultrasound). Thus, in hypotonic-hypokinetic dyskinesia - the gallbladder decreased from 94 + 7.3 cm to 52 ± 4.5 cm3, and in hypertensive-hyperkinetic - increased from 30 ± 2.1 cm3 to 47 ± 3.2 cm, which is also the positive dynamics of indicators of physical and biochemical properties of bile (bile acids, cholesterol, cholato-cholesterol ratio, specific weight and microscopy results) also testifies.

Analyzing the dynamics of the main indicators of the immune system in patients with chronic hepatobiliary pathology, it should be noted the observed decrease in immune reactivity and immune responses in exacerbation of chronic hepatobiliary pathology (chronic cholecystitis, hepatitis), as evidenced by biochemical parameters such as ALT. Increase in indicators: T-lymphocytes, T-active, E-ROK assumes activation of a thymus-dependent chain of immune system. This indicates the attenuation of the acute inflammatory process and the restoration of immune protection.

Patients with dyspeptic syndrome, the appointment of drugs "Lin Chi" requires a differentiated approach, due to the presence in the extract of a small amount of bitterness and sugars.

Conclusion:

Thus, our observations indicate that "Lin Chi" is a modern drug that has cholespasmolytic, cholekinetic effect, has a positive effect on metabolic processes, increases detoxification properties, normalizes homeostasis, reduces cholesterol, increases bile bile acid content.

Lin Chi has a pronounced immunomodulatory, adaptogenic, hypotensive and hepatoprotective effect. Lin Chi is also characterized by anti-allergic and antioxidant effects. Contained in the drugs "Lin Chi" Ganoderma Lucidum is an effective radioprotector, well tolerated by patients with pancreatohepatobiliary pathology and has no side effects. Lin Chi is compatible with traditional medicines, accelerates the healing process and is recommended for the normalization of metabolic processes in the liver, shown in the rehabilitation period after hepatitis, cholecystitis, pancreatitis, liver and pancreatic surgery.